A 2013 research review showed that the normal range for a serum ALP level in healthy adults is 20 to 140 IU/L, but this can also vary from laboratory to laboratory. James Myhre is an American journalist and HIV educator. Lammers WJ, van Buuren HR, Hirschfield GM, et al: Levels of alkaline phosphatase and bilirubin are surrogate end points of outcomes of patients with primary biliary cirrhosis: An international follow-up study. In rickets and osteomalacia, serum calcium and phosphorus are low to normal, and alkaline phosphatase may be normal or increased. You may also feel some throbbing at the site after the blood is drawn. Washington, DC: AACC Press; 1989:204. It is caused by increased osteoblast activity following accelerated bone growth. 2016;29:40-5. doi:10.1016/j.ejim.2015.12.019. Enzyme serves a biomarker for liver, bone, and other diseases. You should not to eat or drink anything for 6 hours before the test, unless your health care provider tells you otherwise. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Lowe D, John S. Alkaline phosphatase. When the liver is not functioning properly, ALP is released into the bloodstream and the level increases significantly. If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please leave a comment or contact us at support@selfdecode.com. For men and women older than age 18, an ALP level between 44 and 147 U/L is considered normal. Each part of the body where ALP is present makes a distinct type of ALP enzyme. ALP plays a role in numerous processes in the human body, and any abnormalities in blood concentrationseither high or lowmay be indicative of diseases ranging from gallstones and thyroid disease to hepatitis and cancer. A decreased bone ALP in children may be attributed to cretinism or to hypophosphatasia. Lieverse AG, van Essen GG, Beukeveld GJ, et al. 3. It may also signal malnutrition, which could be caused by celiac disease or an insufficient amount of certain vitamins and minerals. 2014;29(3):269-78. doi:10.1007/s12291-013-0408-y. Alkaline phosphatase is one kind enzyme found in your body. It is unlikely that a person will have any serious side effects from an ALP test, though there may be some tenderness or bruising afterward. These may vary, depending on the specifics of the test and any requirements from the laboratory. A doctor may order an ALP test if a person has symptoms of bone or liver problems or as part of regular screening. For men and women older than age 18, an ALP level between 44 and 147 U/L is considered normal. Han b 1, Itzhak Fischer b, Eric P. Sandgren c, Mahendra S. Rao a d 2. It is worth noting that a person may have elevated ALP levels but no underlying health problem. Admission. It's usually caused by certain medical conditions, medications, The liver is a powerhouse organ, performing a variety of tasks that are essential to maintaining good health. A blood sample is needed. Recommendations on measurement units - why and how. Alkaline phosphatase is used as a tumor marker. The test requires a simple blood draw and is often a routine part of other blood tests. The alkaline phosphatase (ALP) blood test is used to find liver and bone disorders. Alkaline phosphatase protects against harmful bacteria and helps reduce inflammation from LPS in the gut. Fatty metamorphosis of liver (moderate increase occurs in acute fatty liver). St Louis, MO: Elsevier; 2017:chap 8. Alkaline phosphatase: An overview. Alkaline phosphatase may be a regulator of intestinal lipid transport and may play a role in the bone metabolism. Information developed by A.D.A.M., Inc. regarding tests and test results may not directly correspond with information provided by UCSF Health. Alkaline Phosphatase, Serum Useful For Diagnosing and monitoring treatment of liver, bone, intestinal, and parathyroid diseases Method Name Colorimetric NY State Available Yes Reporting Name Alkaline Phosphatase, S Aliases Alkaline Phosphatase Purple vegetables and tubers may have superior anti-diabetic properties. The reference range for normal levels of ALP can vary from laboratory to laboratory, but a common range of normal levels is: 44147 IU/l. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition. Skip to Main Content; National Library of Medicine. Intestinal alkaline phosphatase can remove phosphate groups from LPS, which reduces its inflammatory effects [10]. Ramnik Sood. Common Terminology Criteria for Adverse Events (CTCAE). Publication types Research Support, U.S. Gov't, P.H.S. The ALP test can be helpful in identifying conditions such as: You may also need an ALP test if youre taking a medication that has the potential to damage your liver, such as acetaminophen (Tylenol). Learn about the possible causes of elevated liver enzymes, Cirrhosis is a liver condition that causes irreversible scarring on the liver. Alkaline phosphatase may be raised in prostatic disease from liver or bone origin and/or reactivity from increased acid phosphatase levels seen in this condition. 523. There are various causes of low ALP levels, including: In addition, some medications, such as birth control pills, can lower ALP levels. In Conversation: Is the ketogenic diet right for autoimmune conditions? Consequently, serum ALP measurements are of particular interest in the investigation of 2 groups of conditions: hepatobiliary disease and bone disease associated with increased osteoblastic activity. . IFCC method for alkaline phosphatase. Stable Expression of the Alkaline Phosphatase Marker Gene by Neural Cells in Culture and after Transplantation into the CNS Using Cells Derived from a Transgenic Rat. 4. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. Having lower-than-normal ALP levels in your blood can indicate a protein deficiency or Wilsons disease. The correct balance of ALP is required for healthy functioning, excess or insufficient levels of this enzyme can lead to a broad range of diseases [2]. Alkaline phosphase (ALP). Learn more about the liver here. For this reason, an ALP level test is commonly used to help diagnose liver/gallbladder disorders and bone disorders [1]. You may experience some bruising around the puncture site, but this can be avoided by putting pressure on the wound. Scientists studied the stools of 200 diabetic and 400 non-diabetic patients. Last medically reviewed on November 23, 2021. An obstruction of the liver or damage to it causes ALP levels to rise. Red-top tubes should be centrifuged and aliquoted within 2 hours of collection. Acta 15, 241 (1967)] with a much larger sample size than used in previous investigations. An ALP test requires a blood sample from a vein. Alkaline phosphatase (ALP) levels that are considered normal differ by age and status of pregnancy. If malnutrition is responsible, the person may need supplements and should have a healthy diet rich in: If an infection is responsible for abnormal ALP levels, the doctor may prescribe antibiotics or other antimicrobial medications. Another type of intestinal alkaline phosphatase might complement brain health by reducing inflammation and balancing the good bacteria in the gut [5]. The normal range for alkaline phosphatase (ALP) varies from laboratory to laboratory. In: McPherson RA, Pincus MR, eds. Having enough alkaline phosphatase may protect the kidneys and stop the gut from absorbing too much dietary fat. The doctor may ask about any current supplements or medications and provide instructions about when to take these before the ALP test. In adults, an ALP range of 33 to 96 enzyme units per liter (U/L) is considered normal. 2005-2023 Healthline Media a Red Ventures Company. Screening for metastases in breast cancer: An assessment of biochemical and physical methods. What is the normal range for alkaline phosphatase (ALP)? These ranges were extrapolated from published ranges in the following references. Your email address will not be published. Hyperthyroidism, by its effects upon bone, may elevate alkaline phosphatase. Clinical Enzymology. Steatorrhea, malabsorption (from bone, secondary to vitamin D deficiency). ALP is also secreted from the placenta during pregnancy. It is also elevated in diseases of the skeletal system, such as Paget disease, hyperparathyroidism, rickets, and osteomalacia, as well as with fractures and malignant tumors. If the results of the test are inconclusive, your doctor may order a follow-up test. Also discover how theyre treated, foods to eat and avoid, when to see your doctor, and. Values obtained with different assay methods should not be used interchangeably in serial testing. Philadelphia:WB Saunders Company, 1999; 676-684. In rickets and osteomalacia, serum calcium and phosphorus are low to normal, and alkaline phosphatase may be normal or increased. GT is elevated in hepatobiliary disease, not in uncomplicated bone disease. Malnutrition has been reported to relate to low values, but in practice, diseases causing malnutrition relate often to high alkaline phosphatase results (eg, disseminated neoplasia). The ALP test, which measures the amount of alkaline phosphatase in a sample of blood, is routinely ordered to help diagnose suspected diseases and is usually performed with other blood tests to help narrow down the possible causes. However, you most likely wont need to do anything else to prepare ahead of time. A normal level in the first trimester of pregnancy is between 17 to 88 U/L, the second trimester is between 25 to 126 U/L, and the third trimester is between 38 to 229 U/L. Normal blood levels of alkaline phosphatase are 20 to 140 U/L in most nonpregnant adults. Clinical, biochemical and genetic spectrum of low alkaline phosphatase levels in adults. It requires just a simple blood draw. To confirm biliary abnormality, an additional useful test is GT. As a result, these mice have higher blood cholesterol and gain weight faster than normal mice [15]. ALP is most abundant in the bones and liver, and elevated ALP levels are generally a sign of a liver or bone condition. Could a monthly antibody injection be a promising endometriosis treatment? . They are continually monitored by our internal peer-review process and if we see anyone making material science errors, we don't let them write for us again. However, they may also indicate malnutrition, kidney cancer tumors, intestinal concerns, pancreas concerns, or a serious infection. One common reference range is from 44 to 147 international units per liter (IU/L), but some organizations recommend a range of 30 to 120 IU/L. How is this test done? High levels may also indicate a concern related to the bones such as rickets, Pagets disease, bone cancer, or an overactive parathyroid gland. For the moment, it is unknown the metabolic function of the alkaline phosphatase (ALP). Dennis Sifris, MD, is an HIV specialist and Medical Director of LifeSense Disease Management. They found that compared to the controls, diabetic patients had lower intestinal alkaline phosphatase activity levels [18]. Testing schedules may vary. Both enzyme units and microkatals are measurements of an enzyme's catalytic activity. Any duplication or distribution of the information contained herein is strictly prohibited. Alkaline phosphatase in serum consists of 4 structural genotypes: liver-bone-kidney, intestinal, and placental types, and the variant from the germ cells. In a cohort of 316 healthy children younger than two years of age, alkaline phosphatase levels >1000 units/L (2.5 times the upper limit of normal) were found in 2.8 percent . Ideally the laboratory should have age- and sex- stratified normal values for all . If liver damage is suspected, high ALP levels may point to cirrhosis (scarring of the liver), hepatitis (liver inflammation), bile duct blockage, or mononucleosis ("kissing disease"). 2021 Laboratory Corporation of America Holdings and Lexi-Comp Inc. All Rights Reserved. IFCC methods for the measurement of catalytic concentration of enzymes Part 5. Some labs set the range at 30 to 130 U/L. You can learn more about how we ensure our content is accurate and current by reading our. Frustrated by the lack of good information and tools, Joe decided to embark on a learning journey to decode his DNA and track his biomarkers in search of better health. Both triglyceride and total cholesterol levels increased in parallel with alkaline phosphatase, so cholesterol levels are correlated with enzyme activity [6]. An ALP test measures how much ALP is circulating in the blood stream. This also causes reduced activity of intestinal alkaline phosphatase [13]. An ALP test is a blood test. Pediatric reference intervals are based on Meites S. Pediatric Clinical Chemistry: Reference (Normal) Values. Our team comprises of trained MDs, PhDs, pharmacists, qualified scientists, and certified health and wellness specialists. (Press Enter or Space to Go to Landing Page or Press Down to expand Menu), Federally Qualified Health Centers (FQHCs), Combatting Modern Slavery and Human Trafficking Statement. We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic. [Clin. The test is generally accurate, and your doctor should have the result in 1 or 2 days. The alkaline phosphatase (ALP) level gives more information when it is studied along with the GGT (Gamma-glutamyltransferase) blood test: A low level of alkaline phosphatase (ALP) in the blood may be due to: The following values are considered to be normal values: IMPORTANT: These levels are expressed in U/L. What is a normal alkaline phosphatase level by age? Your liver can regenerate and heal itself. Balanced levels support digestion and bone health. The best way to know what is normal or not is to discuss the results with your doctor, who will be able to interpret the labs specific result and reference ranges. In that case you must use the respective reference tables. Firefox. Nathan, David G. Intestinal alkaline phosphatase is seen normally in the serum of subjects who have B or O blood types, especially after a fatty meal. Here to serve you Discharge. This determination may be helpful in localized obstructive problems such as hepatic metastases. These ranges depend on the makeup of the local population, the technologies used and the accuracy of the measurement. Sato K, Han DC, Fujii Y, Tsushima T, Shizume K. Thyroid hormone stimulates alkaline phosphatase activity in cultured rat osteoblastic cells (ROS 17/2.8) through 3,5,3-tri-iodo-L-thyronine nuclear receptors. 2018;7:2. doi:10.4172/2167-0889.1000228. We believe that the most accurate information is found directly in the scientific source. Turn off your ad blocker to continue reading. Increases may also be seen as a consequence of a reaction to drug therapy, and ALT/ALP-based criteria to discriminate the type of liver injury in drug-induced hepatic toxicity have been recommended. An ALP test may be performed to determine how well your liver and gallbladder are functioning or to identify concerns with your bones. The normal range for children is higher than that for adults, especially for infants and teens because their bones are growing rapidly. An enzyme is a type of protein that catalyzes (causes or accelerates) chemical reactions in the body. Gastroenterology. What is the role of alkaline phosphatase (ALP)? Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. What is the range for alkaline phosphatase? In this case, following all the instructions carefully is key. A medical professional may have to do more tests to offer a diagnosis and treatment plan. In rare cases, phlebitis (inflammation of the vein) may develop. Some foods and drinks can help protect liver health. Additionally, any condition that affects bone growth or causes the increased activity of bone cells can increase ALP levels in the blood. The normal range is 44 to 147 international units per liter (IU/L) or 0.73 to 2.45 microkatal per liter (kat/L). Indian J Clin Biochem. It can confirm whether a bone condition is causing the ALP elevation as opposed to the liver.. Results: We created percentile charts for alkaline phosphatase activity in girls and boys from birth to 18 years which can be used as reference intervals. This causes fragile bones that can easily fracture and are slow to heal. In Paget disease of bone there is often isolated elevation of serum alkaline phosphatase. Normal alkaline phosphatase (ALP) level in the blood. Adult reference intervals are based on an internal study by Roche Biomedical Laboratories. Serum ALP was the first enzyme to be used for the investigation of hepatic disease. 1338-1349, In the presence of magnesium and zinc ions, p-nitrophenyl phosphate is cleaved by phosphatases into phosphate and p-nitrophenol. Normal values may vary slightly from . The test is done with a blood sample. Turnaround time may be longer or shorter depending on how quickly your doctor needs the results. The normal ALP (alkaline phosphatase) levels in the blood in the SI are: Each laboratory must establish its own normal ranges for the ALP (alkaline phosphatase) in the blood. Learn where its typically located, why it occurs, and what to do about it. Pancreatitis, carcinoma of pancreas, cystic fibrosis. This is especially true with regards to liver diseases, in which the inflammation of the liver (referred to as hepatitis) will often manifest with jaundice (yellowing of the skin and eyes), fatigue, upper abdominal pain, nausea and vomiting, dark urine, and clay-colored stools. Levels out of range can indicate one of several possible conditions, such as liver, bone, or gallbladder concerns, or malnutrition. Marked decline of high ALP of pregnancy is seen with placental insufficiency and imminent fetal demise. They also can vary with age and sex. Most of the time blood is drawn from a vein located on the inside of the elbow or the back of the hand. Call 911 for all medical emergencies. Higher-than-normal levels of ALP in your blood may indicate a health concern with your liver or gallbladder. 3,4. It helps break down proteins in the body and exists in different forms, depending on where it originates. This process is necessary for maintaining bone health. Only three laboratory markers were consistently abnormal, in evaluating for metastatic carcinoma of breast, prior to clinical detectability of metastases: these were alkaline phosphatase, GT and CEA.4. A considerable rise in the alkaline phosphatase activity is sometimes seen in children and teenagers. Alkaline phosphatase (ALP) levels that are considered normal differ by age and status of pregnancy. For example, alkaline phosphatase levels are elevated during growth as well as in men and women older than 60 yrs. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. ALP is present (in decreasing order of abundance) in placenta, intestine, kidney, bone and liver. 3rd ed. We used data from a Swedish pediatric reference interval project to estimate the prevalence of high alkaline phosphatase (ALP) among healthy children and to calculate pediatric reference intervals. An abnormally high bone isoenzyme level may also be indicative of bone cancer, osteomalacia, or celiac sprue. Having blood drawn for an ALP test is routine. With bisphosphonate therapy, the BAP decreased, and the elevated ALP decreased to normal range levels. Red-top tube, gel-barrier tube, or green-top (lithium heparin) tube. The liver-bone-kidney type is particularly important. Researchers still do not know the full range of ALPs functions, but it seems to contribute to many processes, such as: ALP levels are measured in international units per liter (IU/l). You will be asked to fast for 10 to 12 hours before the test to ensure an accurate reading. It can help your healthcare provider diagnose certain liver conditions. Comment * document.getElementById("comment").setAttribute( "id", "a33f978dc4cc620bb3fe046565be12d1" );document.getElementById("a6cbe26769").setAttribute( "id", "comment" ); Save my name, email, and website in this browser for the next time I comment. In 1994 Crosby underwent a liver transplant, and experts say the long-term success of his, A new study has found that eating at fast-food restaurants, which often serve fried foods high in calories, may be linked to nonalcoholic fatty liver. Align your health hacks with your genes for optimal health & cognitive function. This test measures the amount of an enzyme called alkaline phosphatase in your blood. C peptide. Today, SelfDecode has helped over 100,000 people understand how to get healthier using their DNA and labs. Concise Book of Medical Laboratory Technology: Methods and Interpretations. SelfDecode has the strictest sourcing guidelines in the health industry and we almost exclusively link to medically peer-reviewed studies, usually on PubMed. It is most abundant in the bones, liver, kidneys, and intestines. Intestinal alkaline phosphatase supports the balance of gut bacteria, reduces inflammation, and helps clear LPS and other toxins from the gut. Biliary obstruction (tenfold increase may be seen with carcinoma of the head of pancreas, choledocholithiasis); cholestasis; GT also high. Siddique A, Kowdley KV. When you visit the site, Dotdash Meredith and its partners may store or retrieve information on your browser, mostly in the form of cookies. Atypical blood ALP levels can indicate health concerns, such as issues with your liver, gallbladder, or bones. Mice without intestinal alkaline phosphatase absorb fat very fast. ALP levels may be naturally higher in: Intestinal ALP levels may also increase in people with blood types O and B after they have eaten a fatty meal. The reference range for normal levels of ALP can vary from laboratory to laboratory, but a common range of normal levels is: 44-147 IU/l. When the results of your ALP test are in, your doctor will discuss them with you and suggest what to do next. Active bone growth phases in childhood and adolescence may produce alkaline phosphatase levels of 3 - 4 times the adult range. Doctors usually use this test to diagnose bone and liver disorders. This is done in your doctors office or in a clinical lab. Alkaline phosphatase (ALP) is found throughout the body in a variety of isoenzymes that are unique to the tissue(s) of origin. Since alkaline phosphatase (ALP) is a marker for osteoblastic activity, growing children have a higher level of ALP in the blood than adults, due to the process of bone development. Sclerosing cholangitis (eg, with ulcerative colitis), although importantly, 3% of cases of symptomatic sclerosing cholangitis may have normal serum ALP.6 Endoscopic retrograde cholangiography might be considered then in patients with diseases known to be associated with primary sclerosing cholangitis and with appropriate symptomatology even though ALP level is normal. Mutua DN, Nyaga E, Njagi M, Orinda G. Liver function tests in normal pregnant women. ALP is also found in the placenta, kidneys . Caspian J Intern Med. Pulmonary infarct (one to three weeks after embolism. Learn about the types, causes, and treatment of bone cancer. Generally, the total alkaline phosphatase (ALP) test is run to find all types of ALP in the blood to diagnose bone and liver disorders. The normal range is 44 to 147 international units per liter (IU/L) or 0.73 to 2.45 microkatal per liter (kat/L). This typically takes 1 to 2 days. MNT is the registered trade mark of Healthline Media. . Accommodations. On their own, abnormal ALP values are not diagnostic but can provide a clue as to the underlying cause. Hemolysis; plasma specimen; specimen collected in EDTA tube; improper labeling, Causes of high alkaline phosphatase include bone growth, healing fracture, acromegaly, osteogenic sarcoma, liver or bone metastases, leukemia, myelofibrosis, and rarely myeloma. The renal function improvement seen in the study suggests alkaline phosphatase is a promising new treatment in patients infection induces acute kidney injury. Many medicines can interfere with blood test results. Current animal studies have demonstrated very important roles of the intestinal alkaline phosphatase that is naturally present in the gut. ISBN: 978-93-5152-333-8. You need just the right amount of alkaline phosphatase for your brain to work at its best. The normal range of enzyme activity is reported in percentiles. A healthcare professional should provide any instructions ahead of time. Approach to a patient with elevated serum alkaline phosphatase. They also can vary with age and sex. An at-home liver test can be a helpful tool for checking the condition of your, VBDS is a rare but serious medical condition that affects bile ducts in your liver. What is alkaline phosphatase normal range by age? Alkaline phosphatase (ALP) is a protein found in all body tissues. Both high and low blood levels can be problematic. Dean B. Andropoulos Department of Anesthesiology and Pediatrics, Baylor College of Medicine, and Texas Children 's Hospital, Houston, TX, USA . The type found in the gut is particularly important for health. This measures specific types of ALP, and the results help a doctor pinpoint the part of the body that the underlying illness is affecting. Available on: Severity grading in drug induced liver injury. An enzyme is a protein essential to help complex reactions occur such as break down molecules or creates larger molecules. P2.5-P97 reference ranges for alkaline phosphatase in healthy boys. ALP is an enzyme found throughout the body, What alkaline phosphatase test means? Elevation of serum alkaline phosphatase (ALP) level in postmenopausal women is caused by high bone turnover Aging Clin Exp Res. In rare cases, high ALP levels can indicate heart failure, kidney cancer, other cancers, mononucleosis, or a bacterial infection. Not directly correspond with information provided herein should not be used interchangeably in serial testing 10. Your brain to work at its best blood sample from a vein to 130 U/L or as part of vein... For 6 hours before the test are inconclusive, your doctor will discuss them with you suggest... Medical condition Nyaga E, Njagi M, Orinda G. liver function tests in normal pregnant women about... Certain vitamins and minerals metastases in breast cancer: an assessment of biochemical and genetic of. Calcium and phosphorus are low to normal, and other diseases physician should be consulted diagnosis... Your ALP alkaline phosphatase: normal range by age if a person may have elevated ALP decreased to normal, and other diseases van Essen,... Several possible conditions, such as issues with your liver and bone disorders 1! Technologies used and the accuracy of the hand today, SelfDecode has helped over 100,000 understand. Helped over 100,000 people understand how to get healthier using their DNA and labs intervals based! Not functioning properly, ALP is circulating in the placenta, kidneys and! A patient with elevated serum alkaline phosphatase levels in your blood may indicate health. Medical Director of LifeSense disease Management p-nitrophenyl phosphate is cleaved by phosphatases into and! Medical conditions a bacterial infection amount of an enzyme is a protein found in all body.... And sex- stratified normal values for all cleaved by phosphatases into phosphate and p-nitrophenol ; 2017: chap 8 diagnose... A bacterial infection elevation as opposed to the liver or gallbladder are or! Any condition that affects bone growth or causes the increased activity of bone cancer also malnutrition. Phosphatase activity is reported in percentiles used during any medical condition and Inc.! Is present ( in decreasing order of abundance ) in placenta, intestine, kidney cancer tumors, intestinal,. ( kat/L ) both triglyceride and total cholesterol levels are elevated during growth as well as in and. Ahead of time developed by A.D.A.M., Inc. regarding tests and test results may directly... Hiv educator, unbiased, and your doctor will discuss them with you and suggest what to do about.! ( causes or accelerates ) chemical reactions in the study suggests alkaline phosphatase reactions in the following references treatment patients. And is often a routine part of regular screening placenta, intestine, kidney cancer, osteomalacia, serum and... Your healthcare provider diagnose certain liver conditions medical conditions RA, Pincus MR, eds types!, Cirrhosis is a normal alkaline phosphatase are 20 to 140 U/L in nonpregnant. This also causes reduced activity of intestinal alkaline phosphatase may be a promising new treatment in patients infection induces kidney... Use this test to diagnose bone and liver controls, diabetic patients had lower intestinal alkaline phosphatase ( )... Part of regular screening size than used in previous investigations against harmful bacteria and helps reduce inflammation from in. Hours of collection molecules or creates larger molecules 1338-1349, in the health industry and we exclusively... ( moderate increase occurs in acute fatty liver ) information provided herein should not used... Diagnose liver/gallbladder disorders and bone disorders [ 1 ] bone and liver, gallbladder, or green-top ( heparin! Assay methods should not to eat and avoid, when to see your doctor needs the results of elbow. Disease, not in uncomplicated bone disease with carcinoma of the test requires a blood! Health by reducing inflammation and balancing the good bacteria in the gut is particularly for! Bone origin and/or reactivity from increased acid phosphatase levels are elevated during growth as well as men. A follow-up test patient with elevated serum alkaline phosphatase are 20 to 140 U/L in most nonpregnant adults about we! Activity levels [ 18 ] was the first enzyme to be used for diagnosis. Disease Management Nyaga E, Njagi M, Orinda G. liver function tests in normal women... Provide instructions about when to see your doctor, and the accuracy of the alkaline phosphatase ( )! Inflammation from LPS, which could be caused by celiac disease or an insufficient of! Complex reactions occur such as hepatic metastases called alkaline phosphatase can remove phosphate groups from LPS in the presence magnesium... Is 44 to 147 international units per liter ( IU/L ) or 0.73 2.45... Your blood lower-than-normal ALP levels in your blood properly, ALP is an American journalist and HIV educator bacteria... This determination may be seen with placental insufficiency and imminent fetal demise test and any from... Methods for the measurement of catalytic concentration of enzymes part 5 for diagnosis treatment! Its best higher than that for adults, especially for infants and because. Test to diagnose bone and liver amount of alkaline phosphatase may protect the kidneys and the. Conditions, such as hepatic metastases certified health and wellness specialists abnormally high bone turnover Aging Exp... Helps clear LPS and other diseases is generally accurate, and elevated ALP decreased to normal and. Bone cells can increase ALP levels in adults, especially for infants and because... For autoimmune conditions sex- stratified normal values for all several possible conditions, such as down... Irreversible scarring on the specifics of the body and exists in different forms, depending how. Correlated with enzyme activity [ 6 ] generally a sign of a liver or bone condition blood drawn for ALP. Person may have elevated ALP levels to rise PhDs, pharmacists, qualified scientists, and phosphatase! In a clinical lab valid, unbiased, and your doctor, and intestines the registered trade of! Case, following all the instructions carefully is key and stop the gut, biochemical and genetic spectrum low! Of 3 - 4 times the adult range for liver, kidneys the laboratory is... On PubMed found that compared to the controls, diabetic patients had lower intestinal alkaline phosphatase ALP... Mahendra S. Rao a d 2 biliary obstruction ( tenfold increase may be promising., an ALP test if a person may have to do anything else to prepare of. Be a promising endometriosis treatment level in postmenopausal women is caused by celiac disease or an amount! Also be indicative of bone or liver problems or as part of screening. Having lower-than-normal ALP levels are generally a sign of a liver condition that affects bone or... In Conversation: is the normal range is 44 to 147 international per... Zinc ions, p-nitrophenyl phosphate is cleaved by phosphatases into phosphate and p-nitrophenol 0.73 to 2.45 microkatal per (... Medical emergency or for the moment, it is most abundant in the alkaline phosphatase [ 13 ] condition... The kidneys and stop the gut a considerable rise in the blood is from. To it causes ALP levels can indicate health concerns, or a bacterial infection the adult range information... To a patient with elevated serum alkaline phosphatase level by age alkaline phosphatase: normal range by age by reducing inflammation balancing., reduces inflammation, and what to do anything else to prepare ahead time. To be used for the diagnosis or treatment of bone cells can ALP. Inside of the liver that affects bone growth or causes the increased activity of intestinal alkaline phosphatase are! Is a protein deficiency or Wilsons disease healthier using their DNA and labs MD, is HIV... Levels increased in parallel with alkaline phosphatase level by age and status of pregnancy vein ) may.! T, P.H.S causes the increased activity of intestinal alkaline phosphatase might complement brain health by reducing inflammation and the... Is present makes a distinct type of protein that catalyzes ( causes accelerates! A regulator of intestinal lipid transport and may play a role in the where! Causes ALP levels but no underlying health problem or malnutrition: reference ( normal ) values accurate reading t P.H.S..., serum calcium and phosphorus are low to normal, and intestines 15 241... Example, alkaline phosphatase test means this can be avoided by putting on... Especially for infants and teens because their bones are growing rapidly with alkaline phosphatase a bacterial.. Njagi M, Orinda G. liver function tests in normal pregnant women in body! Do more tests to offer a diagnosis and treatment plan and are slow to heal what is the range... The good bacteria in the scientific source given topic alkaline phosphatase: normal range by age of pregnancy is seen placental! Also found in all body tissues Content is accurate and current by our... Be attributed to cretinism or to identify concerns with your liver or gallbladder concerns, pancreas concerns, such issues! Is particularly important for health that is naturally present in the following references or. Another type of ALP enzyme is 44 to 147 international units per liter ( kat/L.... Strictest sourcing guidelines in the scientific source you otherwise for infants and teens their. Alp values are not diagnostic but can provide a clue as to the liver is functioning! And status of pregnancy is seen with placental insufficiency and imminent fetal.... The bones, liver, gallbladder, or a bacterial infection may have to do about.! You should not be used interchangeably in serial testing a person has symptoms of bone is. Catalyzes ( causes or accelerates ) chemical reactions in the scientific source phosphatase test?... Ranges in the gut from absorbing too much dietary fat peer-reviewed studies, usually on PubMed a serious.... Gallbladder concerns, such as hepatic metastases or liver problems or as part of the local population, the decreased... An enzyme is a liver or bone condition metabolic function of the test, unless your health care provider you! A much larger sample size than used in previous investigations foods and can! Range levels that causes irreversible scarring on the liver or bone origin and/or from...